A Comparison Study between Isogeometric Analysis and Finite Element Analysis for Nonlinear Inelastic Dynamic Problems with Geomiso DNL Software

The new Geomiso DNL software is proposed to facilitate the use of isogeometric analysis for nonlinear inelastic dynamic applications. This hybrid software solution combines isogeometric analysis and 3D design with advanced spline techniques, such as NURBS and Tsplines. Its dual nature satisfies the rising industrial need for unification of the fields of computer-aided design (CAD) and computer-aided analysis (CAE), as it eliminates geometric errors by merging geometry design with mesh generation into a single procedure. This paper presents sample nonlinear applications in structural dynamics. Geomiso DNL is seen to handle these situations remarkably well, as the numerical examples exhibit significantly improved accuracy of the results, and reduced computational cost, when compared with finite element software packages. It is argued that Geomiso DNL is a new, more efficient, alternative to FEA software packages. This is the first time ever such a cloud-based program has been developed

Isogeometric representations for digital twins subjected to dynamic excitations with GEOMISO DNL software

The new Geomiso DNL software is proposed to facilitate the use of isogeometric analysis for nonlinear inelastic dynamic applications. This hybrid software solution combines isogeometric analysis and 3D design with advanced spline techniques, such as NURBS and Tsplines. Its dual nature satisfies the rising industrial need for unification of the fields of computer-aided design (CAD) and computer-aided analysis (CAE), as it eliminates geometric errors by merging geometry design with mesh generation into a single procedure. This paper presents sample nonlinear applications in structural dynamics. Geomiso DNL is seen to handle these situations remarkably well, as the numerical examples exhibit significantly improved accuracy of the results, and reduced computational cost, when compared with finite element software packages. Geomiso DNL is not just a plug-in, but a both on-premises and cloud-based software, which enables engineers to simulate complex dynamic phenomena, whose impact on industrial products and structures in real-world environments can be more efficiently estimated. Taking advantage of the new horizons offered in the peak of the Industry 4.0 era, the physical twin feeds, via cloud technology, with real-time data its geometrically exact digital twin, while a dynamic analysis is performed and crucial results about structure safety and quality are obtained. It is argued that Geomiso DNL is a new, more efficient, alternative to FEA software. This is the first time ever such a cloud-based program has been developed

An Integrated Approach for Dynamic Charging of Electric Vehicles by Wireless Power Transfer - Lessons Learned from Real-Life Implementation

The aim of this paper is to introduce a complete fast dynamic inductive charging infrastructure from the back-office system (EV management system) up to the Electric Vehicle (EV) (inductive power transfer module, positioning mechanism, electric vehicle modifications) and the EV user (User interface). Moreover, in order to assess the impact of the additional demand of inductive charging on the grid operation, an estimation of the 24-hour power profile of dynamic inductive charging is presented considering, apart from the road traffic, the probability of the need for fast charging, as well as the specifications of the proposed solution. In addition, an energy management system is presented enabling the management of the operation of the inductive charging infrastructure, the interaction with the EV users and the provision of demand response services to different stakeholders. The proposed dynamic inductive charging approach has been demonstrated within a real urban environment in order to provide useful insights regarding the experience gained from a real-field trial. The relevant practical conclusions are also discussed in this paper. Finally, a cost/benefit analysis, according to the Discounted Cash Flow (DCF) principles, is performed in order to assess the economic viability of the proposed solution.This work was supported by the European Commission within the 7th Framework Programme, Project FastInCharge under the Grant Agreement: 31428

Methodology on Quantification of Sonication Duration for Safe Application of MR Guided Focused Ultrasound for Liver Tumour Ablation

Background and objective Magnetic Resonance Guided Focused Ultrasound (MRgFUS) for liver tumour ablation is a challenging task due to motion caused by breathing and occlusion due the ribcage between the transducer and the tumour. To overcome these challenges, a novel system for liver tumour ablation during free breathing has been designed. Methods The novel TRANS-FUSIMO Treatment System (TTS, EUFP7) interacts with a Magnetic Resonance (MR) scanner and a focused ultrasound transducer to sonicate to a moving target in liver. To meet the requirements of ISO 13485; a quality management system for medical device design, the system needs to be tested for certain process parameters. The duration of sonication and, the delay after the sonication button is activated, are among the parameters that need to be quantified for efficient and safe ablation of tumour tissue. A novel methodology is developed to quantify these process parameters. A computerised scope is programmed in LabVIEW to collect data via hydrophone; where the coordinates of fiber-optic sensor assembly was fed into the TRANS-FUSIMO treatment software via Magnetic Resonance Imaging (MRI) to sonicate to the tip of the sensor, which is synchronised with the clock of the scope, embedded in a degassed water tank via sensor assembly holder. The sonications were executed for 50 W, 100 W, 150 W for 10 s to quantify the actual sonication duration and the delay after the emergency stop by two independent operators for thirty times. The deviation of the system from the predefined specs was calculated. Student's-T test was used to investigate the user dependency. Results The duration of sonication and the delay after the sonication were quantified successfully with the developed method. TTS can sonicate with a maximum deviation of 0.16 s (Std 0.32) from the planned duration and with a delay of 14 ms (Std 0.14) for the emergency stop. Student's T tests indicate that the results do not depend on operators (p > .05). Conclusion The evidence obtained via this protocol is crucial for translation- of-research into the clinics for safe application of MRgFUS. The developed protocol could be used for system maintenance in compliance with quality systems in clinics for daily quality assurance routines

Synthesis of diphenoxyadamantane alkylamines with pharmacological interest.

In this work, the synthesis and the pharmacological evaluation of diphenoxyadamantane alkylamines Ia-f and IIa-f is described. The new diphenoxy-substituted adamantanes share structural features present in trypanocidal and antitubercular agents. 1-Methylpiperazine derivative Ia is the most potent against T. brucei compound, whilst its hexylamine congener IIf exhibits a significant antimycobacterial activity

User-Centred Design of a Final Results Report for Participants in Multi-Sensor Personal Air Pollution Exposure Monitoring Campaigns

Using low-cost portable air quality (AQ) monitoring devices is a growing trend in personal exposure studies, enabling a higher spatio-temporal resolution and identifying acute exposure to high concentrations. Comprehension of the results by participants is not guaranteed in exposure studies. However, information on personal exposure is multiplex, which calls for participant involvement in information design to maximise communication output and comprehension. This study describes and proposes a model of a user-centred design (UCD) approach for preparing a final report for participants involved in a multi-sensor personal exposure monitoring study performed in seven cities within the EU Horizon 2020 ICARUS project. Using a combination of human-centred design (HCD), human-information interaction (HII) and design thinking approaches, we iteratively included participants in the framing and design of the final report. User needs were mapped using a survey (n = 82), and feedback on the draft report was obtained from a focus group (n = 5). User requirements were assessed and validated using a post-campaign survey (n = 31). The UCD research was conducted amongst participants in Ljubljana, Slovenia, and the results report was distributed among the participating cities across Europe. The feedback made it clear that the final report was well-received and helped participants better understand the influence of individual behaviours on personal exposure to air pollution